Artemisinins - an important class of antimalarial drug Essay

Artemisinins - an important class of antimalarial drug - Essay Example In order to check the statistical significance of the observations, Mutations were introduced in various mammalian and Plasmodium isolates. ATPase assay was performed to determine Ki values of each drug on the mutant as compared to its wild-type SERCA. The introduction of Leucine at position 263 in place of Alanine in the Plasmodium vivax search resulted in a 3 fold increase (Ki=63nM+/-12) as compared to wild-type PfATP6 (Ki=169+/-31) in the sensitivity of Artemisinin. Whereas the introduction of leucine at position 263 in the place of serine in P.berghei decreases the sensitivity by 3-fold (Ki= 530nm+/-84). IC50 values showed P.vivax (IC50-1.3nM)is more susceptible to artesunate than P.falciparum(IC50-4.2nM).Artemisone a semisynthetic derivative of artemisinin is more potent against PvSERCA (